Subscribe to e-Fido.net
Powered by groups.yahoo.com
e-Fido.net logo









Departments




















Gene Therapy Shows Promise for Sightless Dogs | BARFing for Health

Gene Therapy Shows Promise for Sightless Dogs
By Warren Richardson, Executive Editor

Being the "eyes" for a blind person has long been the task for guide dogs. But who sees for blind dogs?

Now, breakthrough research in gene therapy at the University of Pennsylvania indicates a way to restore not only sight to blind dogs, but to blind humans as well.

Supported by a grant from the Foundation Fighting Blindness, the scientists used a virus to deliver new genes and restore sight to a dog suffering from the canine model of a severe childhood blindness known clinically as Leber congenital amaurosis (LCA). Their findings, published in the May issue of "Nature Genetics," represents the first time researchers successfully restored vision in a large animal model of retinal degeneration.

"With this study, gene therapy has overcome a major hurdle," says Dr. Gerald Chader, chief scientific officer of the foundation. "Previous researchers have restored vision in rodents. However, the Food and Drug Administration wants to see evidence that a treatment is safe and effective in a large animal model before granting permission to begin clinical trials in humans. Genetic medicine is now making things we could only once dream of a reality."

Usually, in humans and animals, a normal protein carries a Vitamin A-like compound that is necessary for sight to the retina. In individuals and animals with LCA, the protein that transports the compound is missing from the gene, which results in blindness. Using a recombinant virus, researchers at the University of Pennsylvania injected three dogs that suffered from LCA with replacement genes carrying the protein.

Within 90 days, the dogs' eyes exhibited waveforms similar in scope to that of a sighted dog's eyes.

Behavioral testing followed a month later, and the dogs all avoided collision with objects.

"The results are spectacular," says Dr. Jean Bennett, an associate professor of ophthalmology at the university. "They are the sort of findings that a scientist usually only hopes to, but rarely does, see in the course of a career. This study takes a great stride forward in demonstrating that gene therapy does not just slow down a retinal degenerative disease, but can actually provide recovery of vision to an animal that was previously blind."


BARFing for Health
by Lesli Richardson, Editor

Sounds gross, doesn't it? But according to thousands of pet owners, with their numbers growing every day, it's the best way to feed your dog.

BARF stands for Bones and Raw Foods, or Biologically Appropriate Foods, depending on your preference. (It's also often referred to as an "evolutionary diet.") The diet is based largely on several books including "Give Your Dog a Bone" by Dr. Ian Billinghurst, "Natural Nutrition for Dogs & Cats: The Ultimate Diet" by Kymythy Schultze, and "Dr. Pitcairn's Complete Guide to Natural Health for Dogs & Cats" by Richard Pitcairn, DVM, and Susan Pitcairn.

Practitioners of a BARF diet feed a combination of raw, meaty bones, raw meats, vegetables, and other uncooked items such as fish, tripe and liver along with dietary supplements such as essential vitamins and minerals. A majority of pet owners feeding their dogs a BARF diet claim to have had astounding results with their animals, resulting in anything from lower quantities and less obnoxious stools to reversals in medical conditions such as allergies and arthritis.

Unfortunately, no major studies have been done by a reputable university or other organization to give solid numbers to the claims, but there are vets who have researched the diet and support their clients' decision to use it for their pets.

Detractors of the diet (which include many vets and pet food companies) claim that the diet can sicken pets in a best-case scenario, or even kill due to problems with bacterial infections from improperly handled raw foods and splintering bones.

People who practice the BARF diet say that these are rare occurrences, and can happen with dogs that are fed commercially prepared foods. Many BARFers (as they call themselves) grind meat with smaller bones, such as chicken and ribs, to prevent problems from splintering. The ones that don't usually don't have problems, since raw bones don't splinter like cooked bones do. They say that it's a small price to pay to have a healthier pet.

Pros to the BARF diet include:

  • guaranteed better quality of food
  • more natural diet
  • food allergy relief
  • possible health benefits (there is plentiful anecdotal evidence, but unfortunately no scientific data)

Cons to the BARF diet include:

  • increased cost and preparation time
  • risk of serious illness/death if the diet isn't followed properly
  • possible risk of bacterial infection from improperly handled foods
  • possible risk of internal injury from bones that aren't ground

Until the diet is scrutinized in an academic study, the debate will rage on between the factions who claim their side is right. There is, however, a disturbing trend that many of the more vocal dissenters are ones who, upon further examination, either haven't studied the diet or profit in some way from sales of commercial food. This would give a careful pet owner cause to independently research both methods of feeding, talk to their vet as well as others, talk to people who have been using the BARF diet for their pets, and make their own decision based on research and not hyped-up hysteria. There are many websites and e-mail list available to people wanting to learn more about this diet.

Bone appetite!




New in This Issue
(Vol. 1 - Issue 2)

Ask Genevieve
BARF Diet
Basenji Breed Profile
Clicker Training
Crufts Report
Disaster Preparedness
The Dogs of Deer Mountain (Part 2)
Editorial
Gene Therapy Restores Sight
Nutrition for the Critical Patient
Product Review: Kongs
Water Dogs
Website Review


 
 

Website copyright 2001, e-Fido.net
Web Design by Lesli Richardson
No part of this website may be reproduced
in part or in whole without the express permission
of the publisher.
Links may be created to this site and are welcomed.
All articles are copyrighted by the authors.
e-Fido.net and all related logos are copyrighted. All rights reserved.
The Dogpile search box is used in accordance
with their terms and e-Fido.net claims no affiliation,
licensing, or partnership with them other
than what is stated in their free-useage agreement.